The Exposure Amount of Paraben from Commercial Toothpaste
안금선, 박용덕, 유수민,
소속 상세정보
안금선 ( Ahn Geum-Sun ) - Kyungbok University Department of Dental Hygiene
박용덕 ( Park Yong-Duk ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry
유수민 ( Yoo Su-Min ) - Kyungdong University Department of Dental Hygiene
KMID : 1157520140100010031
Abstract
Objective: Parabens, which have cytotoxic activity, are widely used preservatives in personal care products. In this study, theexposure amounts of paraben during toothpaste usage were predicted by analyze the paraben concentration in commercialdentifrices using high-performance liquid chromatography.
Methods: Commercial toothpaste from different manufacturer were extracted in methanol, diluted with distilled water tomake concentration 0.5 mg/L. Four parabens (methylparaben, ethylparaben, propylparaben, and butylparaben) in toothpastesamples were separated by high-performance liquid chromatography using C18 column and 50% acetonitrile at 20oC, thendetected at ultraviolet 256 nm.
Results: The analytical method showed good precision and accuracy. Any parabens weren’t detected in toothpastes from onemanufacturer, and were detected in toothpastes from other two manufacturer except ethylparabens. The exposed total parabensper one brushing was maximally 1.8 mg.
Conclusion: The amount of parabens from toothpaste was predicted to be insignificant compared to other routes (cosmetics,foods); however, it is need to minimize the use of parabens in toothpaste.
키워드
parabens; toothpastes; mouth mucosa; chromatography
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